diff --git a/src/backend/demo/management/commands/create_demo.py b/src/backend/demo/management/commands/create_demo.py
index 7973e73..4634d63 100755
--- a/src/backend/demo/management/commands/create_demo.py
+++ b/src/backend/demo/management/commands/create_demo.py
@@ -21,7 +21,11 @@ from core import models
 
 from demo import defaults
 from mailbox_manager import models as mailbox_models
-from mailbox_manager.enums import MailboxStatusChoices, MailDomainStatusChoices
+from mailbox_manager.enums import (
+    MailboxStatusChoices,
+    MailDomainRoleChoices,
+    MailDomainStatusChoices,
+)
 
 fake = Faker()
 
@@ -366,6 +370,19 @@ def create_demo(stdout):  # pylint: disable=too-many-locals
 
         queue.flush()
 
+        # Enabled domain for 2E2 tests
+        enabled_domain, _created = mailbox_models.MailDomain.objects.get_or_create(
+            name="enabled-domain.com",
+            status=MailDomainStatusChoices.ENABLED,
+            support_email="support@enabled-domain.com",
+        )
+        domain_owner = models.User.objects.get(email="e2e.mail-owner@example.com")
+        mailbox_models.MailDomainAccess.objects.get_or_create(
+            domain=enabled_domain,
+            user=domain_owner,
+            role=MailDomainRoleChoices.OWNER,
+        )
+
     # OIDC configuration
     if settings.OAUTH2_PROVIDER.get("OIDC_ENABLED", False):
         stdout.write("Creating OIDC client for People Identity Provider")
diff --git a/src/backend/demo/tests/test_commands_create_demo.py b/src/backend/demo/tests/test_commands_create_demo.py
index 3b93fcd..bb6a2f9 100644
--- a/src/backend/demo/tests/test_commands_create_demo.py
+++ b/src/backend/demo/tests/test_commands_create_demo.py
@@ -40,13 +40,14 @@ def test_commands_create_demo(settings):
 
     assert models.Team.objects.count() == TEST_NB_OBJECTS["teams"]
     assert models.TeamAccess.objects.count() >= TEST_NB_OBJECTS["teams"]
-    assert mailbox_models.MailDomain.objects.count() == TEST_NB_OBJECTS["domains"] + 1
+    assert mailbox_models.MailDomain.objects.count() == TEST_NB_OBJECTS["domains"] + 1 + 1
 
     # 3 domain access for each user with domain rights
     # 3 x 3 domain access for each user with both rights
+    # 1 domain for E2E mail owner user
     assert (
         mailbox_models.MailDomainAccess.objects.count()
-        == TEST_NB_OBJECTS["domains"] + 3 + 9
+        == TEST_NB_OBJECTS["domains"] + 3 + 9 + 1
     )
 
 
diff --git a/src/frontend/apps/e2e/__tests__/app-desk/mail-domain.spec.ts b/src/frontend/apps/e2e/__tests__/app-desk/mail-domain.spec.ts
index 02f880b..8ecfede 100644
--- a/src/frontend/apps/e2e/__tests__/app-desk/mail-domain.spec.ts
+++ b/src/frontend/apps/e2e/__tests__/app-desk/mail-domain.spec.ts
@@ -192,6 +192,89 @@ test.describe('Mail domain', () => {
           page.getByText('No mail box was created with this mail domain.'),
         ).toBeVisible();
       });
+
+      test('can disable and enable mailbox', async ({ page, browserName }) => {
+        await page.goto('/');
+        await keyCloakSignIn(page, browserName, 'mail-owner');
+
+        await clickOnMailDomainsNavButton(page);
+
+        // Go to the enabled-domain.com management page
+        await expect(page).toHaveURL(/mail-domains\//);
+        await expect(
+          page.getByText('enabled-domain.com', { exact: true }),
+        ).toBeVisible();
+        await page
+          .getByLabel(`enabled-domain.com listboxDomains button`)
+          .click();
+        await expect(page).toHaveURL(/mail-domains\/enabled-domaincom\//);
+        await expect(
+          page.getByRole('heading', { name: 'enabled-domain.com' }),
+        ).toBeVisible();
+
+        // Click new mailbox button
+        await page.getByTestId('button-new-mailbox').click();
+
+        // Fill in mailbox form with random string
+        const randomString = Math.random().toString(36).substring(2, 8);
+        await page.getByLabel('First name').fill('John');
+        await page.getByLabel('Last name').fill('Doe');
+        await page.getByLabel('Name of the new address').fill(randomString);
+        await page
+          .getByLabel('Personal email address')
+          .fill(`${randomString}@example.com`);
+
+        // Submit form
+        await page.getByRole('button', { name: 'Create' }).click();
+
+        // Verify success toast appears
+        await expect(page.getByText('Mailbox created!')).toBeVisible();
+
+        // Verify mailbox appears in list
+        await expect(
+          page.getByText(`${randomString}@enabled-domain.com`),
+        ).toBeVisible();
+
+        // Click the options button for the specific mailbox
+        await page
+          .getByRole('row', { name: `${randomString}@enabled-domain.com` })
+          .getByLabel('Open the access options modal')
+          .click();
+
+        // Click disable button
+        await page.getByText('Disable mailbox').click();
+
+        // Verify modal appears
+        await expect(
+          page.getByText('Are you sure you want to disable this mailbox?'),
+        ).toBeVisible();
+
+        // Click disable in modal
+        await page.getByRole('button', { name: 'Disable' }).click();
+
+        // Verify mailbox status shows as disabled
+        await expect(
+          page
+            .getByRole('row', { name: `${randomString}@enabled-domain.com` })
+            .getByText('Disabled'),
+        ).toBeVisible();
+
+        // Click options button again
+        await page
+          .getByRole('row', { name: `${randomString}@enabled-domain.com` })
+          .getByLabel('Open the access options modal')
+          .click();
+
+        // Click enable button
+        await page.getByText('Enable mailbox').click();
+
+        // Verify mailbox status shows as enabled
+        await expect(
+          page
+            .getByRole('row', { name: `${randomString}@enabled-domain.com` })
+            .getByText('Enabled'),
+        ).toBeVisible();
+      });
     });
 
     test.describe('mail domain creation is pending', () => {